BUY OXANDROLONE (ANAVAR) — 10 MG/TAB. – 100 TABS
Oxandrolone 10 is described in the supplied information as a 17-alpha-alkylated anabolic steroid that promotes anabolic activity through androgen receptor activity.
The source states that oxandrolone does not aromatise to oestrogen. It also describes reported applications involving strength, muscle mass, body-fat reduction, nerve regeneration, skin healing in burn victims and recovery following traumatic events.
Clinical Pharmacology
Anabolic steroids are synthetic derivatives of testosterone. Their clinical effects and adverse reactions demonstrate androgenic properties, and complete separation of anabolic and androgenic effects has not been achieved.
Anabolic steroids may suppress gonadotrophic pituitary function. During exogenous administration of anabolic androgens, endogenous testosterone release can be inhibited through suppression of pituitary luteinising hormone (LH). At larger doses, spermatogenesis may be suppressed through feedback inhibition of follicle-stimulating hormone (FSH).
The supplied pharmacokinetic information reports a mean elimination half-life of 13.3 hours in elderly subjects and 10.4 hours in younger subjects following single-dose studies.
Indications and Usage
According to the supplied product information, Oxandrolone 10 is indicated as an alternate or adjunctive therapy for:
Promotion of weight gain following weight loss.
Muscular atrophy associated with extensive surgery.
Muscular atrophy associated with chronic infections.
Muscular atrophy associated with long-term hospitalisation.
Muscular atrophy associated with severe trauma.
Compensation for protein catabolism resulting from corticosteroid therapy.
Reduction of pain associated with osteoporosis.
Contraindications
The supplied information lists contraindications including:
Diagnosed or suspected carcinoma of the breast, prostate or testis.
Pregnancy or the possibility of pregnancy because of possible masculinisation of the fetus.
Nephrosis or the nephrotic phase of nephritis.
Hypercalcaemia.
Pre-existing cardiac, respiratory, renal and/or hepatic disease.
History of epilepsy.
Precautions
The supplied information warns that elevated liver enzymes and, in extreme cases, hepatic dysfunction may occur. As a 17-alpha-alkylated androgen, oxandrolone may cause cholestatic hepatitis and jaundice, particularly with larger doses or prolonged treatment.
The source recommends monitoring liver function, including serum bilirubin, AST, ALT and alkaline phosphatase.
Anabolic steroid hormones may increase LDL and decrease HDL levels. The supplied information also states that anabolic steroids may reduce clotting factors II, V, VII and X and increase prothrombin time.
Patients taking warfarin or experiencing irregular bleeding should inform their healthcare professional.
In patients with diabetes, androgens may alter the metabolism of oral hypoglycaemic medicines or insulin sensitivity and may require adjustment of diabetes treatment.
Adverse Reactions
Reported adverse reactions include:
Male: Gynaecomastia, excessive frequency and duration of penile erections and oligospermia.
Skin and Appendages: Hirsutism, pattern baldness and acne.
Fluid and Electrolyte Disturbances: Retention of sodium, chloride, water, potassium, calcium and inorganic phosphates.
Gastrointestinal and Hepatic: Nausea, cholestatic jaundice and alterations in liver function tests. Rare reactions include hepatocellular neoplasms, peliosis hepatitis, hepatic adenomas and cholestatic hepatitis.
Hematologic: Suppression of clotting factors II, V, VII and X, with bleeding possible in patients receiving anticoagulant therapy.
Nervous System: Increased or decreased libido, headache, anxiety, depression and generalised paraesthesia.
Metabolic: Increased serum creatinine phosphokinase (CPK), reduced glucose tolerance, increased creatinine clearance and inhibition of gonadotrophin secretion.
Other: Serum lipid changes, hypercalcaemia, hypertension, oedema, priapism and potentiation of sleep apnoea.
Drug Interactions
The supplied information identifies potential interactions with:
Oral hypoglycaemic agents: Oxandrolone may inhibit their metabolism and may require dosage adjustment.
Anticoagulants: Anabolic steroids may increase sensitivity to oral anticoagulants. Patients receiving anticoagulant therapy require careful monitoring.
The source recommends regular monitoring during anabolic steroid therapy, particularly when treatment is initiated or discontinued.
Dosage and Administration
The supplied information states a dosage for adult males of 10–30 mg orally per day, taken in 2–3 divided doses for 6–8 weeks under the care of a physician.
Dosage and treatment duration should be determined by a qualified healthcare professional according to the individual clinical circumstances.
Presentation
Oxandrolone 10 mg uncoated tablets, supplied as 100 tablets in one bottle.
Storage
Store in a cool, dry place between 15–25°C. Protect from light.
